1 in 1000 women have this almost-undetectable genetic mutation.

1 in 1000 women have this almost-undetectable genetic mutation.

This syndrome occurs in women who inherit three X chromosomes. Their genotype is XXX or more rarely XXXX or XXXXX.

As adults, these "super-females" or "metafemales", as they are sometimes known, generally are an inch or so taller than average with unusually long legs and slender torsos but otherwise appear normal.

They usually have normal development of sexual characteristics and are fertile but tend to have some ovary abnormalities that can lead to premature ovarian failure.

They may have slight learning difficulties, especially in speech and language skills, and are usually in the low range of normal intelligence.

They frequently are very tall in childhood and tend to be emotionally immature for their size. The frequency is approximately 1 in 1,000 female infants and it occurs more commonly when the mother is older.

(Source)

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